CURRICULUM VITAE
Robert Mark Merion, MD
Division of Transplantation University of Michigan Medical Center 2926 Taubman Center, Box 0331 Ann Arbor, Michigan 48109-0331 ACADEMIC APPOINTMENTS: Chief, Division of Transplantation Department of Surgery University of Michigan Medical Center Ann Arbor, Michigan Associate Professor of Surgery Division of Transplantation Department of Surgery University of Michigan Medical School Ann Arbor, Michigan BIBLIOGRAPHY Completed publications in scientific journals: Peer reviewed: 1. Merion RM, Harness JK, Ramsburgh SR, Thompson NW. Selective management of penetrating neck trauma. Arch Surg 1981; 116: 691-6. 2. Merion RM, White DJG, Calne RY. Early renal allograft rejection episodes are less aggressive with cyclosporin A immunosuppression. Transplant Proc 1983; 15: 2172-7. 3. Rolles K, Merion RM, Calne RY. Conversion problem: azathioprine to cyclosporin. Transplant Proc 1983: 15: 2878-80. 4. Merion RM, White DJG, Thiru S, Evans DB, Calne RY. Cyclosporine: five years' experience in cadaveric renal transplantation. New Engl J Med 1984; 310: 148-54. 5. Merion RM, White DJG. Nephrotoxicity of cyclosporine (Letter to the Editor). New Engl J Med 1984; 312: 49. 6. Merion RM. Measurements of reticuloendothelial system phagocytic activity in the rat after treatment with silica, liposomes and cyclosporine. Transplantation 1985; 40: 86-9. 7. Merion RM, Calne RY. Allograft renal vein thrombosis. Transplant Proc 1985; 17: 1746-50. 8. Merion RM, Greatorex RA, Calne RY. Delayed acute rejection episodes in patients with kidney grafts given cyclosporine immunosuppression. Ann Surg 1985; 201: 444-6. 9. Drakopoulos S, White, DJG, Merion RM, Winter S, Calne RY. An assessment of the clinical value of monitoring cyclosporine plasma levels. Transplant Proc 1985; 17: 1258-9. 10. Dafoe DC, Campbell DA, Marks WH, Borgstrom A, Merion RM, Berlin RE, Turcotte JG. Detrimental effects of four hours of cold storage on porcine pancreaticoduodenal transplantation. Surgery 1986; 99: 170-7. 11. Merion RM, Campbell DA, Averill DA, Dafoe DC, Fantone JC, Turcotte JG. Improved liver preservation with Eurocollins and donor allopurinol. Transplant Proc 1986; 18: 582-7. 12. Tagge E, Campbell D, Reichle R, Merion R, Dafoe D, Schwartz R, Rosenberg L, Turcotte J, Juni J. Quantitative hepatic scintigraphy to evaluate ischemic/reperfusion injury in porcine liver transplantation. Transplant Proc 1987; 19: 1095-7. 13. Tagge EP, Campbell DA, Reichle R, Averill DR, Merion RM, Dafoe DC, Turcotte JG, Juni J. Quantitative scintigraphy with deconvolutional analysis for the dynamic measurement of hepatic function. J Surg Res 1987; 42: 605-12. 14. Dafoe DC, Campbell DA, Merion RM, Rosenberg L, Rocher LL, Vinik AI, Vine AK, Turcotte JG. Pancreatic transplantation - University of Michigan. Transplant Proc 1987; 19: 55-62. 15. Tagge EP, Campbell DA, Dafoe DC, Merion RM, Sedman AB, Kelsch RC, Mollen E, Rocher LL, Turcotte JG. Pediatric renal transplantation with an emphasis on the prognosis of patients with chronic renal insufficiency since infancy. Surgery 1987; 102: 690-8. 16. Dafoe DC, Rosenberg L, Campbell DA, Merion RM, Lichter AS, Turcotte JG. Clinical pancreaticoduodenal allotransplantation with inclusion of the donor spleen (irradiated and non-irradiated) to prevent thrombosis. Transplant Proc 1988; 20: 876-7. 17. Merion RM, Campbell DA, Dafoe DC, Rosenberg L, Turcotte JG, Juni JE. Observations on quantitative scintigraphy with deconvolutional analysis in liver transplantation. Transplant Proc 1988; 20: 695-7. 18. Merion RM, Campbell DA, Dafoe DC, Rosenberg L, Rocher LL, Turcotte JG. Predictors of outcome in cyclosporine-treated recipients of second renal transplants. Transplant Proc 1988: 20: 194-7. 19. Ohl DA, Konnak JW, Campbell DA, Dafoe DC, Merion RM, Turcotte JG. Extravesical ureteroneocystostomy in renal transplantation. J Urol 1988; 139: 499-502. 20. Von Moll LK, Juni JE, Merion RM. Scintigraphic demonstration of accessory hepatic duct leak following liver transplantation. J Nucl Med 1988; 29: 259-62. 21. Dafoe DC, Campbell DA, Merion RM, Rosenberg L, Turcotte JG, Vinik AI, Pek SB, Sanfield J, Rocher LL, Wolf F, Anderson B, Harrison VA, Loftin J, Dennerll E, Prey PA, Halloran SA, Fox ME, Waskerwitz JA, O'Neil MK, Vine AK, Clifford M. Pancreatic transplantation as treatment for IDDM: proposed candidate criteria before end-stage diabetic nephropathy. Diabetes Care 1988; 11:669-74. 22. Rosenberg L, Merion RM, Campbell DA, Dafoe DC, Clarke S, Rocher LL, Turcotte JG. Peripheral blood catalase activity in patients undergoing renal transplantation. J Surg Res 1988; 44:493-8. 23. Merion RM, Delius RE, Campbell DA, Turcotte JG. Orthotopic liver transplantation totally corrects factor IX deficiency in hemophilia B. Surgery 1988; 104:929-31. 24. Manning PB, Merion RM, Dafoe DC, Campbell DA, Turcotte JG. Peritoneovenous shunt: A new method of treatment for recurrent peritransplant lymphocele. Clin Transplantation 1988; 2: 85-6. 25. Rosenberg L, Granke K, Campbell DA, Dafoe DC, Merion RM, Turcotte JG. Procurement of kidneys with anomalies: long-term outcome. Transplant Proc 1988: 20: 768-9. 26. Lloyd RV, Dafoe DC, Campbell DA, Merion RM, Turcotte JG, Vinik AI. Pancreas transplantation: an immunohistochemical analysis of pancreatic hormones and HLA-DR expression. Modern Pathol 1989; 2:323-30. 27. Rocher LL, Hodgson RJ, Merion RM, Swartz RD, Keavey S, Turcotte JG, Campbell DA. Amelioration of chronic renal allograft dysfunction in cyclosporine-treated patients by addition of azathioprine. Transplantation 1989; 47: 249-54. 28. Dafoe DC, Campbell DA, Rosenberg L, Merion RM, Ucros I, Vinik A, Klandorf H, Turcotte JG. Does exogenous insulin infusion (islet "rest") improve pancreas transplant endocrine function? Transplant Proc 1989; 21: 2827-8. 29. Nestor ZJ, Rocher LL, Merion RM, Swartz RD, Turcotte JG, Campbell DA. Peri-operative antilymphoblast globulin and delayed initiation of cyclosporine diminishes the requirement for prolonged dialysis therapy after renal transplantation. Transplant Proc 1989; 21: 1556-7. 30. Rocher LL, Hodgson RJ, Merion RM, Swartz RD, Keavey SA, Turcotte JG, Campbell DA. The course of chronic, progressive renal allograft dysfunction during cyclosporine therapy is modified by addition of azathioprine. Transplant Proc 1989; 21: 1529-31. 31. Merion RM, Burtch GD, Turcotte JG, Campbell DA. The hepatic artery in liver transplantation. Transplantation 1989; 48: 438-43. 32. Burtch GD, Merion RM. Transdiaphragmatic exposure for direct atrial- caval anastomosis in liver transplantation for Budd-Chiari syndrome. Transplantation 1989; 47:161-3. 33. Dafoe DC, Campbell DA, Rosenberg L, Merion RM, Ucros I, Vinik A, Klandorf H, Turcotte JG. Does exogenous insulin infusion (islet rest) in the post-operative period improve pancreas transplant endocrine function? Transplantation 1989; 48:22-6. 34. Merion RM, Colletti LM. Hyperacute rejection in porcine liver transplantation. I. Clinical characteristics, histopathology, and disappearance of donor-specific lymphocytotoxic antibody from serum. Transplantation 1990; 49: 861-8. 35. Merion RM, Gorski DH, Burtch GD, Turcotte JG, Campbell DA. Bile refeeding after liver transplantation and avoidance of intravenous cyclosporine. Surgery 1989; 106: 604-10. 36. Goyal DG, Gutowski KA, Merion RM. Estimation of in vivo reticuloendothelial system phagocytic activity in rats by direct blood clearance techniques and nuclear scintigraphy. J Leukocyte Biol 1990; 48: 60-6. 37. Lucey MR, Kolars JC, Merion RM, Campbell DA, Aldrich M, Watkins PB. Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA. Lancet 1990; 335:11-15. 38. Merion RM, Oh HK, Port FK, Toledo-Pereyra LH, Turcotte JG. A prospective controlled trial of cold storage versus machine perfusion preservation in cadaveric renal transplantation. Transplantation 1990; 50: 230-3. 39. Beresford TP, Turcotte JG, Merion RM, Burtch G, Blow FC, Campbell D, Brower KJ, Coffman K, Modell JG, Lucey M. A rational approach to liver transplantation for the alcoholic. Psychosomatics 1990; 31: 241-54. 40. Morse JH, Turcotte JG, Merion RM, Campbell DA, Burtch GD, Lucey MR. Development of a malignant tumor in a liver transplant graft procured from a donor with a cerebral neoplasm. Transplantation 1990: 50: 875-7. 41. Campbell DA, Merion RM, Ham JM, Lucey MR, Henley KS, Turcotte JG. Hepatic preservation with University of Wisconsin solution is associated with reduced allograft rejection. Transplant Proc 1991; 23: 1547-9. 42. Watts RWE, Morgan SH, Danpure CJ, Purkiss P, Calne RY, Rolles K, Baker LR, Mansell MA, Smith LH, Merion RM, Lucey MR. Combined hepatic and renal transplantation in primary hyperoxaluria type I: clinical report of nine cases. Am J Med 1991; 90: 179-88. 43. Merion RM, Twork AM, Rosenberg L, Ham JM, Burtch GD, Turcotte JG, Rocher LL, Campbell DA. Obesity in renal transplantation. Surg Gynecol Obstet 1991; 172:.367-76. 44. Merion RM, Turcotte JG, Ham JM, Lucey MR, Henley KS, Campbell DA. Early immunological benefits of glutathione-supplemented UW solution in hepatic transplantation. Transplant Proc 1991; 23: 2243-5. 45. Campbell DA, Ham JM, McCurry KR, Lucey MR, Turcotte JG, Merion RM. Liver transplant for fulminant hepatic failure. Am Surg 1991; 57: 546- 9. 46. Merion RM, Campbell DA. Split liver transplanatation: one plus one doesn't always equal two (Editorial review). Hepatology 1991; 14: 572-4. 47. Kolars JC, Awni WM, Merion RM, Watkins PB. First-pass metabolism of cyclosporin by the gut. Lancet 1991; 338: 1488-90. 48. Lucey MR, Merion RM, Henley KS, Campbell DA Jr, Turcotte JG, Nostrant TT, Blow F, Beresford TP. Selection for and outcome of liver transplantation in patients with alcoholic liver disease. Gastroenterology 1992; 102: 1736-41. 49. McCurry KR, Baliga P, Merion RM, Ham JM, Lucey MR, Beresford TP, Turcotte JG, Campbell DA. Resource utilization and outcome of liver transplantation for alcoholic cirrhosis - a case control study. Arch Surg 1992;127: 772-7. 50. Henley KS, Lucey MR, Appelman HD, Baliga P, Brown KA, Burtch GD, Campbell DA, Ham JM, Merion RM, Turcotte JG. Biochemical and histopathological correlation in liver transplant: the first one hundred eighty days. Hepatology 1992; 16: 688-93. 51. Platt JF, Marn CS, Baliga PK, Ellis JH, Rubin JM, Merion RM. Renal dysfunction in hepatic disease: early identification with renal duplex Doppler US in patients who undergo liver transplantation. Radiology 1992; 183: 801-6. 52. Baliga P, Merion RM, Turcotte JG, Ham JM, Henley KS, Lucey MR, Schork A, Shir Y, Campbell, DA. Preoperative risk factor assessment in liver transplantation. Surgery 1992; 112: 704-11. 53. Lucey MR, Graham DM, Martin P, DiBisceglie A, Rosenthal S, Waggoner JG, Merion RM, Campbell DA, Nostrant TT, Appelman HD. Recurrence of hepatitis B and delta hepatitis following orthotopic liver transplantation. Gut 1992; 33: 1390-6. 54. Lown K, Kolars J, Turgeon K, Merion RM, Wrighton F, Watkins P: The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease. Clin Pharmacol Ther 1992; 51: 229-38. 55. Beresford TP, Schwartz J, Wilson D, Merion RM, Lucey MR. The short term psychological health of alcoholic and non-alcoholic liver transplant recipients. Alcohol Clin Exp Res 1992; 16: 996-1000. 56. Hennein HA, Mendeloff EN, Turcotte JG, Ham JM, Baliga P, Campbell DA, Merion RM. Aortic revascularization of orthotopic liver allografts: indications and long-term follow up. Surgery 1993; 113: 271-85. 57. Bunchman TE, Kershaw DB, Merion RM, Ham JM, Sedman AB, Kelsch RC, Walter MB, So S. OKT3 reversal of biopsy-proven allograft rejection occurring during Minnesota antilymphoblast globulin induction in the pediatric renal recipient. Clin Transplantation 1993; 7: 219-22. 58. Bunchman TE, Kershaw DB, Merion RM, Ham JM, Sedman AB, Walter MB, Kelsch RC. T cell subset analysis by flow cytometry during MALG induction for pediatric renal transplantation. Transplantation 1993; 55: 1190-3. 59. Bunchman TE, Ham JM, Sedman AB, Kershaw DB, Turcotte JG, Campbell DA, Punch JD, Merion RM. Superior allograft survival in pediatric renal transplant recipients. Transplant Proc 1994; 26: 24-5. 60. Colletti LM, Johnson KJ, Kunkel RG, Merion RM. Mechanisms of hyperacute rejection in porcine liver transplantation: antibody-mediated endothelial injury. Transplantation 1994; 57: 1357-63. 61. Ham JM, Bunchman TE, Campbell DA, Kershaw DB, Punch JD, Sedman AB, Turcotte JG, Merion RM. Cytomegalovirus and Epstein-Barr virus - acquired immunity after Sandoglobulin prophylaxis in the pediatric renal transplant population. Transplant Proc 1994; 26: 20-1. 62. Platt JF, Ellis JH, Rubin JM, Merion RM, Lucey MR. Renal duplex Doppler ultrasonography: a non-invasive predictor of kidney dysfunction and hepatorenal failure in liver disease. Hepatology 1994; 20: 362-9. 63. Turgeon DK, Leichtman AB, Lown KS, Normolle DP, Deeb GM, Merion RM, Watkins PB. P450IIIA(CYP3A) activity and cyclosporin A dosing in renal and cardiac transplant recipients. Clin Pharmacol Ther 1994; 56: 253-60. 64. Kolars JC, Lown KS, Schmiedlin-Ren P, Ghosh M, Fang C, Wrighton SA, Merion RM, Watkins PB. CYP3A gene expression in human gut epithelium. Pharmacogenetics 1994; 4: 247-59. 65. Teitelbaum DH, Narasimhan A, Chenault RH, Merion RM. Lymphocyte immunologic interactions in intestinal transplantation. Transplant Proc 1994; 26: 1525-6. Articles accepted for publication: 1. Punch JD, Merion RM, Thompson NW. Hyperparathyroidism associated with end stage renal disease and transplantation. Acta Chir Austriaca (in press). 2. Henley KS, Lucey MR, Normolle DP, Merion RM, McLaren ID, Crider BA, Mackie DS, Shieck VL, Nostrant TT, Brown KA, Campbell DA, Ham JM, Appelman HD, Turcotte JG. A double-blind, randomized, placebo- controlled trial of prostaglandin E1 in liver transplantation. Hepatology (in press). 3. Reis G, Marcovitz PA, Leichtman AB, Merion RM, Fay WP, Werns S, Armstrong WF. Usefulness of dobutamine stress echocardiography for detecting coronary artery disease in end-stage renal disease. Am J Cardiol (in press). Articles submitted for publication: 1. Lucey MR, Newman MG, Brown KA, Baliga P, Beresford TP, Ham JM, Turcotte JG, Campbell DA, Henley KS, Merion RM. What determines selection?: an analysis of the selection process among patients referred for liver transplant evaluation. Hepatology (submitted). 2. Marn CS, Rubin JM, Platt JF, Adler RS, Francis IR, Merion RM. Arteriovenous shunts in cirrhosis: pitfalls in the Doppler evaluation of focal hepatic lesions. Radiology (submitted). 3. Bunchman TE, Sedman AB, Kershaw DB, Sanvordenker JK, Campbell DA, Turcotte JG, Punch JD, Merion RM. Cyclosporine dosing and timing: impact upon allograft outcome, hospitalization time and cost in the young pediatric kidney transplant recipient. Transplantation (submitted). 4. Merion RM, Woodside KJ, Chenault RH, Gupta S. Donor-specific prolongation of skin allograft survival following intraportal allogeneic cell inoculation. Transplantation (submitted). 5. Mass K, Quint EH, Punch MR, Merion RM. Gynecologic and reproductive function after liver transplantation. Obstet and Gynecol (submitted). 6. Punch JD, Thompson NW, Merion RM. A twenty-five year single center experience with subtotal parathyroidectomy for secondary and tertiary hyperparathyroidism. Arch Surg (submitted). Books: 1. Liver transplantation and the alcoholic patient. MR Lucey, RM Merion, TP Beresford (Eds.), Cambridge University Press, Cambridge, 1994. Chapters in books: 1. Youmans LC, Merion RM. "The office of surgical education: administration of educational activities", in Medical Education: A Surgical Perspective, RH Bartlett, GB Zelenock, WE Strodel, M Harper, JG Turcotte (Eds.), Lewis Publishers, Inc., Chelsea, Michigan, 1986. 2. Turcotte JG, Campbell DA, Dafoe DC, Merion RM, Konnak JW. "Immunobiology and transplantation of the kidney", in Hardy's Textbook of Surgery, JD Hardy (Ed.), J. B. Lippincott Co., Philadelphia, 1988. 3. Turcotte JG, Campbell DA, Dafoe DC, Merion RM, Sedman AB, Rocher LL, Konnak JW, Kelch RC. "Pediatric renal transplantation", in Organ Transplantation and Replacement, GJ Cerilli (Ed.), JB Lippincott Co., Philadelphia, 1988. 4. Dafoe DC, Campbell DA, Merion RM, Rosenberg L, Rocher LL, Vinik AI, Turcotte JG. "Pancreas transplant experience of individual institutions: experience of the University of Michigan Medical School, Ann Arbor, Michigan USA", in International Handbook of Pancreas Transplantation, JM Dubernard, DER Sutherland (Eds.), Kluwer Academic Publishers, Dordrecht, 1989. 5. Campbell DA, Merion RM. "Complications of renal transplantation", in Complications of Surgery and Trauma, LJ Greenfield (Ed.), JB Lippincott Co., Philadelphia, 1989. 6. Campbell DA, Burtch GD, Merion RM . "Ischemic dysfunction following organ transplantation", in Clinical Ischemic Syndromes: Mechanisms and Consequences of Tissue Injury, GB Zelenock, LG D'Alecy, JC Fantone, M Shlafer, JC Stanley, (Eds.), CV Mosby Company, St. Louis, 1989. 7. Turcotte JG, Merion RM, Burtch GD, Ham JM, Lucey MR, Henley KS, Campbell DA. "Liver transplantation at the University of Michigan", in Clinical Transplants 1989, P Terasaki (Ed.), UCLA Tissue Typing Laboratory, Los Angeles 1989. 8. Turcotte JG, Campbell DA, Merion RM, Burtch GD, Ham JM. "Hepatic transplantation", in Surgery of the Alimentary Tract, GD Zuidema (Ed.), WB Saunders Company, Philadelphia, 1991. 9. Merion RM. "Organ preservation", in Surgery: Scientific Principles and Practice, LJ Greenfield (Ed.), JB Lippincott Co., Philadelphia, 1992. 10. Campbell DA, Ham JM, Turcotte JG, Merion RM. "Hepatic transplantation", in Surgery: Scientific Principles and Practice, LJ Greenfield (Ed.), JB Lippincott Co., Philadelphia, 1992. 11. Campbell DA, Merion RM, McCurry KR, Lucey MR, Ham JM, Baliga P, Beresford TP, Turcotte JG. "The role of liver transplantation in the management of the patient with variceal hemorrhage", in Problems in General Surgery, E Rypius (Ed.), JB Lippincott Co., Philadelphia, 1992. 12. Campbell DA, Merion RM, Ham JM, Turcotte JG. "Liver transplantation for hepatic neoplasm", in Current Therapy in Oncology, JE Niederhuber (Ed.), BC Decker., Philadelphia, 1993. 13. Merion RM. "Outcome of liver transplantation for alcohol-related liver disease", in Liver transplantation and the alcoholic patient, MR Lucey, RM Merion, TP Beresford (Eds.), Cambridge University Press, Cambridge, 1994. 14. Merion RM. "Vascular complications after liver transplantation", in Liver Transplantation: Practice and Management, J Neuberger, MR Lucey (Eds.), BMJ Publishing Group, London, 1994. 15. Punch JD, Merion RM. "External methods of angioaccess", in Current Therapy in Vascular Surgery, CB Ernst, JC Stanley (Eds.), Mosby-Year Book, Inc., Philadelphia (in press). 16. Merion RM. "Principles of transplantation: kidney", in Rob and Smith's Operative Surgery: Pediatric Surgery, L Spitz, AG Coran (Eds.), Chapman and Hall, Ltd., London, 1995. 17. Punch JD, Merion RM. "Organ preservation", in Surgery: Scientific Principles and Practice, LJ Greenfield (Ed.), JB Lippincott Co., Philadelphia (in press). 18. Turcotte JG, Campbell DA, Bromberg JS, Punch JD, Henley KS, Hillimeier AC, Merion RM. "Hepatic transplantation", in Surgery of the Alimentary Tract, GD Zuidema (Ed.), WB Saunders Company, Philadelphia (in press).
